Long-sought Discovery Fills in Missing Details of Cell ‘Switchboard’

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SLAC’s X-ray Laser Lends New Insight into Key Target for Drug Development

Menlo Park, Calif. — A biomedical breakthrough, published today in the journal Nature, reveals never-before-seen details of the human body’s cellular switchboard that regulates sensory and hormonal responses. The work is based on an X-ray laser experiment at the Department of Energy’s SLAC National Accelerator Laboratory.

The much-anticipated discovery, a decade in the making, could have broad impacts on development of more highly targeted and effective drugs with fewer side effects to treat conditions including high blood pressure, diabetes, depression and even some types of cancer. (read more)

Press releaseSLAC

July 22, 2015Glenn Roberts

This illustration shows arrestin (yellow), an important type of signaling protein, while docked with rhodopsin (orange), a G protein-coupled receptor. GPCRs are embedded in cell membranes and serve an important role in a cellular signaling network. An experiment conducted at SLAC’s Linac Coherent Light Source X-ray laser provided an atomic-scale 3-D map of this joined structure. (SLAC National Accelerator Laboratory)
This illustration shows arrestin (yellow), an important type of signaling protein, while docked with rhodopsin (orange), a G protein-coupled receptor. GPCRs are embedded in cell membranes and serve an important role in a cellular signaling network. An experiment conducted at SLAC’s Linac Coherent Light Source X-ray laser provided an atomic-scale 3-D map of this joined structure. (SLAC National Accelerator Laboratory)
In crystallography experiments at the Coherent X-ray Imaging experimental station at LCLS, a liquid jet delivers nanoscale crystals into this chamber, where X-ray laser pulses strike them. (SLAC National Accelerator Laboratory)
In crystallography experiments at the Coherent X-ray Imaging experimental station at LCLS, a liquid jet delivers nanoscale crystals into this chamber, where X-ray laser pulses strike them. (SLAC National Accelerator Laboratory)

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Citation: Y. Kang, et al., Nature, 22 July 2015 (10.1038/nature14656)

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